At stake in Friday's 11 p.m. EST (0400 GMT Saturday) Mega Millions drawing is a $450 million prize, the fourth-largest in its history with a $281 million payout if the victor selects a lump-sum payment.
Winning a portion of the largest jackpot ever can cause some legal issues and unwanted advances from some who want a cut of the prize.
Hoosiers have a chance to win a fortune this weekend in the lottery.
The Powerball draw, which takes place on Saturday, has its fifth-largest jackpot, standing at $570m (£420m). The insane jackpots mark the third time in lottery history that the two combined have reached nearly one billion dollars.
At the KJ's Superstore in Malad, the lottery line has remained steady.
Americans spent $80.5 billion on lottery games past year, according to the North American Association of State and Provincial Lotteries.
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Mega Millions is played in 44 states, Washington D.C. and the U.S. Virgin Islands. The Powerball Jackpot has reached $570 million. Mega Millions tickets are offered in the same locations excluding Puerto Rico.
Mega Millions rises to $445 million.
No one has hit either jackpot since October, allowing the totals to balloon.
Officials warn that more than one ticket will not increase your odds and recommend playing within your means.
The estimated totals are before taxes are assessed.
Two competing American lotteries - Powerball and Mega Millions - have a combined jackpot of over $1bn (£737m) after going months without a jackpot victor. This is still the fourth-largest jackpot in Mega Millions history and the 11th-largest jackpot in US lottery history.