"Twelve targets, including three aerial defense batteries and four Iranian targets that are part of Iran's military establishment in Syria, were attacked", the Israeli IDF said in a statement. The IDF said one was in serious condition, and the other was lightly wounded.
Israel's Prime Minister Benjamin Netanyahu likewise warned on Saturday that the Jewish State "holds Iran and its Syrian hosts responsible for today's aggression".
The Saturday statement on Central Military Media, which is allied with the Syrian military, called a subsequent Israeli attack on a drone station in 's central Homs province a "terrorist act", warning of "a tough and serious response".
Israeli military spokesman Lt. Col. Jonathan Conricus said Iran is playing with fire by infiltrating Israeli airspace and will pay a heavy price for it. Netanyahu pointed out that he has "been warning for some time about the dangers of Iran's military entrenchment in Syria".
Following the downing of the jet, Israel carried out what an Air Force general said was the "largest and most significant" strike in Syria since 1982.
Russian Federation has expressed concern and called for calm after Israeli missile strikes struck 12 Syrian and Iranian targets in Syria, including an aerial defence system. Hezbollah, which has sent thousands of fighters to back the troops of Syrian President Bashar Assad, said the developments mean "a decisive end to old arrangements".
Earlier, the IDF said that a combat helicopter successfully intercepted an Iranian UAV that was launched from Syria and infiltrated Israel.
Syrian state news agency SANA said Syrian air defenses were responding to a "new Israeli aggression" and a military source said the defenses had thwarted attacks on military positions in the south of the country. The cause of the F-16 crash is being investigated, Conricus said, adding that the IDF has not determined if anti-aircraft fire hit the jet.
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The senior commander said the Zionist regime has been created by the USA and the United Kingdom, adding the Islamic Republic of Iran began to inflict heavy blows on the U.S. since early years of the Islamic Revolution.
The incident in and of itself is a serious event and raises questions as to whether the drone was used as bait by the Iranians to drag Israeli jets into Syria, whose air defenses were laying in wait for them.
Syrian State TV quoted a military official Saturday saying that Syrian air defenses hit more than one Israeli plane. The military also says it struck Iranian targets in that launched the drone.
Iran, along with Russian Federation - which had helped prop up the Assad government - denied that any of its drones had entered Israeli air space or that they had any role in shooting down the Israeli jet.
The two pilots of the Israeli F-16 ejected before it crashed in northern Israel; both were reported as "safe" but.
United Nations soldiers look out on a post at Mount Avital, in the Golan Heights near the Israeli Syrian border, February 10, 2018.
A second pilot was lightly injured while abandoning the aircraft.