"I'm sure it'll be tough but he's watched our games from afar and I know he's itching to get back", acting coach Larry Drew said before the game.
Lue said he experienced chest pains and "other troubling symptoms" when the 40-year-old announced he was stepping away from the team on March 19 to address his health.
James scored in double digits in his 867th straight game, breaking the record he shared with his boyhood idol Jordan, and the Cleveland Cavaliers rallied to beat the New Orleans Hornets 107-102 on Friday night to avoid slipping in the standings.
The plan is for him to hopefully ease his way back into a full-time coaching role over the Cavs' four-game homestand that extends until Thursday, sources told ESPN's Adrian Wojnarowski.
Now, he feels he's ready to begin the process of getting back to coaching.
Tinubu elated as Buhari asks APC NEC not to elongate Oyegun's term
President Buhari had in his address told members of the APC National Executive Council (NEC) in Abuja that the tenure elongation was illegal.
At 45-30, the Cavaliers are third in the East, just a half game ahead of Philadelphia and the Pacers. They're going to need all the help they can get, including Ty Lue on board and healthy. On the glass, Tristan Thompson corralled 14 boards, with Kevin Love also hauling down eight despite a rough shooting night.
J.R. Smith was also available after missing shootaround with an illness. Jose Calderon played some minutes for Hill and scored five points.
Jrue Holiday led the Pelicans (43-33) with 25 points and Nikola Mirotic, who was shooting 29 percent from the field in his previous 10 games, had 20 points and seven rebounds.
The Cavs entered Friday with a 36-0 record this season in games where they led after three quarters.
The Cavs had a season-low six turnovers Wednesday in Charlotte.