Syrian television reported that a scientific research center had been hit.
The Syrian regime, however, fired about 40 surface-to-air missiles at incoming missiles or aircraft, but most seemed to lack effective guidance systems and were not effective, the Pentagon said.
Her Russian counterpart, Vassily Nebenzia, called for a Security Council vote condemning the strikes.
"Syria is a strong country, but our allies Russian Federation and Iran make us stronger", she said.
"Good souls will not be humiliated", Syria's presidency tweeted after airstrikes began.
Although the operation was secretly unfolding for hours before the first impact, it only took minutes from the first to the last detonation from 105 precision-guided missile strikes on three Syrian chemical weapons targets, officials said. Colonel-General Sergei Rudskoi on Saturday said Russian Federation may consider supplying S-300 missile systems to Syria.
The US president claimed that the joint action was meant to establish a "strong deterrent" against the production, spread, and use of chemical weapons. That evidence includes victim statements, images of barrel bomb fragments and reliable reports of Syrian government helicopters in the area.
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In this image provided by the U.S. Navy, the guided-missile cruiser USS Monterey (CG 61) fires a Tomahawk land attack missile on April 14, 2018, as part of the military response to Syria's use of chemical weapons on April 7.
The bombing represents a major escalation in the West's confrontation with Assad's superpower ally Russian Federation, but is unlikely to alter the course of a multi-sided war which has killed at least half a million people in the past seven years. He called on Moscow to change course and join the West in seeking a more responsible regime in Damascus. Paris released a dossier which it said showed Damascus was to blame for the poison gas attack on Douma, the last town holding out in a rebel-held swathe of territory near Damascus which government forces have recaptured in this year's biggest offensive.
Other strikes targeted an army depot near Homs.
The attack also drew criticism from many of Trump's most ardent supporters in the US. But Friday night, the White House released what it said was "a significant body of information" that pointed to the use of chlorine gas - and possibly also the deadly nerve agent sarin.
In his nationwide address, Trump stressed that he has no interest in a longtime fight with Syria.
"The American, French and British aggression against Syria will fail", it said.
"We look forward to the day when we can bring our warriors home".
"We are not looking for a confrontation and refuse any logic of escalation", said Parly. They are in eastern Syria, far from Damascus.