After enduring a rocky start to life at the club, he has become a key player for United and, as such, has consistently been linked with moves away.
Real have wanted De Gea in their goal for at least three years, with the Spain No.1 nearly moving to the Bernabeu in 2015 before the deal collapsed at the last minute.
When asked about a potential summer departure for De Gea, the United boss responded: "No chance".
The Spanish goalkeeper has enjoyed another outstanding campaign between the sticks and there is fresh speculation Real Madrid will move for the 27-year-old.
European Central Bank keeps interest rates, guidance unchanged
Draghi also warned in Washington last week that rising protectionism might already be hurting business and consumer sentiment. The main refi rate is now at a record low zero percent and the deposit rate at -0.40 percent.
"He was playing in our competition [the Premier League] for years, we all know how good he was, that's why he was chased by so many teams, I believe", said Mourinho.
But his recent display's in the Manchester Derby victory and FA Cup semi-final triumph over Tottenham last weekend has seen the Chilean earn plaudits from United supporters and English media alike, ahead of the fixture against United's firece rivals.
"We spoke in the Euros and he told me he wanted me with him and wanted trophies". I hope so and feel so, but what I'm sure about is next season.