Unfortunately, the structure of the World Cup 2018 brackets and the venues allocated mean that, in the event Portugal advances to the Last 4, they would be playing against either Brazil, Mexico, Belgium or Japan in Saint Petersburg.
Portugal's Cristiano Ronaldo will be foremost in the minds of Uruguay defenders, while the Europeans' back line must be wary of the threat forwards Luis Suarez and Edinson Cavani pose atop the South Americans' attack. They are the only side yet to concede a goal in the World Cup but they have not been seriously tested having played two minnows in Egypt and Saudi Arabia, and a second-string Russian team in their final group game.
Santos' side dominated the match for large portions but were defeated by two excellent goals from Uruguay talisman Edinson Cavani either side of Pepe's equaliser.
That was the first goal the twice World Cup champions had conceded in the tournament in Russian Federation, but another moment of brilliance from Cavani put them back ahead seven minutes later at the packed Fisht Stadium overlooking the Black Sea.
On the same day Lionel Messi was sent home in Argentina's loss, the other "GOAT" at this tournament was also eliminated. Record-breaking captain Cristiano Ronaldo starred with four goals including a hat-trick against Spain and the victor against Morocco.
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He is the last Argentinean player to score against France , back in February 2009 in a friendly (2-0). France and Argentina will officially kick things off in the 2018 FIFA World Cup Round of 16 .
"Now is not the time to talk about the future of players and coaches", Ronaldo said.
With 20 minutes to play, Bernardo Silva had a huge chance to haul Portugal level again after Muslera spilled a ball in the box, but the Manchester City playmaker fired his shot over the crossbar.
According to Federation Internationale de Football Association, at 31 he is the oldest Uruguayan to score a World Cup brace, 108 days older than Diego Forlan who scored twice against South Africa in 2010. "There is a tournament in September, the Uefa League of Nations, and we hope that he is with us so that he can help the young players who will need their captain's example".
"We must go back with our heads high and with the confidence that this team will keep winning things". The quarter-final clash that I might see from the Fisht stadium would feature either Spain or Russian Federation against Croatia or Denmark.
Uruguay progressed from their group with a ideal record of three wins from three.