Kok Soo Chon, the chief investigator, told reporters that the team of 19 worldwide investigators did not uncover evidence that the pilots or any of the passengers could have been behind the disappearance.
And while Monday's conclusions were billed by the Malaysian government as the final report into the mystery, Kok said it wasn't the last word because "the answer can only be conclusive if the wreckage is found".
The recorded changes in the aircraft flight path following waypoint IGARI, heading back across Peninsular Malaysia, turning south of Penang to the north-west and a subsequent turn towards the Southern Indian Ocean were hard to attribute to any specific aircraft system failures.
Kok said the team looked into the pilot and first officer's background.
The report also highlighted that the two cargo items of interest, the lithium ion batteries and mangosteens, carried on MH370 were in fact packed and loaded according to standard operating procedures.
She said the government should consider any offers by companies who are willing to conduct the search for the plane on "no cure, no fee" basis.
Copies of the MH370 briefing report are seen at the press conference in Putrajaya July 30, 2018.
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The final voice communication from the cockpit came less than an hour after takeoff: "Good night, Malaysian three seven zero".
It said without the benefit of the examination of the aircraft wreckage and recorded flight data information, "the investigation was unable to identify any plausible aircraft or systems failure mode that would lead to the observed systems deactivation, diversion from the filed flight plan route and the subsequent flight path taken by the aircraft".
It also concluded that all four of MH370's emergency locator transmitters (ELT), malfunctioned, meaning they did not give off the normal distress signals which would help locate the plane.
The Kuala Lumpur Air Traffic Control lost contact with the doomed flight at 1:19am Malaysia time.
The disappearance of the flight has become the world's greatest aviation mystery.
It was the second major search after Australia, China and Malaysia ended a fruitless $147 million search across an area of 120,000 sq km previous year.
Mr Shah's sister, Sakinab Shah, said the report put to rest the theory that her brother was responsible for the plane's disappearance, either through incompetence or in a suicide mission. But that search was called off after failing to find anything. What prompted Captain Zaharie Ahmad Shah or anyone else onboard to turn back the plane and veer off to the Southern Indian Ocean without indicating the reasons or distress to the ATC remains unanswered in the report released today. Alhough more than 20 items of debris suspected or confirmed to be from the aircraft have washed ashore on coastlines across the Indian Ocean since then, the body of Boeing 777 has never been found.
There have been a host of theories about why the plane disappeared, ranging from an accident to a hijacking or even a terror plot.