"Don't let that happen!"
The situation around Idlib will be one of the main items on the agenda when the leaders of Russia, Iran and Turkey meet in Tehran this week, Peskov told reporters on a conference call, declining to elaborate further.
The Russian military has initiated a large-scale air-campaign targeting more than 20 villages and hamlets across Al-Qaeda-dominated province of Idlib.
Syrian forces are massing around the northwestern province of Idlib, in preparation for the assault.
Towns and villages in the northern Idlib province, where Syria's rebels are holed up, came under intense airstrikes throughout Tuesday, killing at least eight people, according to a search and rescue group and a conflict monitoring group.
The UN has warned that an attack on Idlib, where 2.9 million people live, "will overwhelm capacities and has the potential to create a humanitarian emergency at a scale not yet seen through this crisis".
In this photo released by the Syrian official news agency SANA, Syrian President Bashar Assad, right, speaks with Iranian Foreign Minister Mohammad Javad Zarif in Damascus, Syria, Monday, Sept 3, 2018.
In the statement from the Syrian President's office, Assad and Zarif said that resorting to "threats and pressure reflect the failure of those countries to realize their plans for the region after Syria and Iran confronted them".
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"Terrorists must be purged" from Idlib and Syrian government control of the province restored, Zarif said in Damascus, according to Iranian media.
Located near the Turkish border, Idlib has been designated as a de-escalation zone where acts of aggression are expressly forbidden as part of the ongoing Astana process. "It is from there (Idlib) that drones are launched to threaten our temporary bases [in Syria]", Peskov said.
ICG said Russian Federation, whose air support would be crucial for the offensive to succeed, should understand that a bloodbath in Idlib would jeopardize its own political goals.
But Israeli Defense Minister Avigdor Lieberman on Monday signalled strikes could be extended to Iraq if necessary.
Britain, France and the United States, which together launched limited attacks on Syrian installations in mid-April in retaliation for an alleged Syrian chemical attack, say their red line against illegal weapon use remains in force.
But analysts still say the United States appears resigned to the likelihood of a final military victory by Syrian government forces.
Trump has sought better relations with Russian Federation since taking office in 2017 but the United States has been unable to rein in Moscow's military and diplomatic support for Assad.