Djokovic, the sixth seed, tamed the Argentine big artillery 6-3, 7-6 (4), 6-3 in three hours and 15 minutes, in the US Open final on Sunday, Xinhua news agency reported.
"If you told me in February this year when I got the surgery that I'll win Wimbledon, US Open, and Cincinnati, it would be hard to believe", said Djokovic, referring to August's Cincinnati Masters that completed his Masters collection. Three unforced errors resulted on that side, with Djokovic forcing an error on the final point as he overturned a 3-1 deficit. The pain of defeat stung, sure, but the emotions were as much a culmination of a tough stint since that maiden US Open title all those years ago. They went back and forth, through eight deuces and all those break opportunities for del Potro, until he slapped one forehand into the net, and another sailed wide.
But against one of the best returners in the business, Del Potro needed to be far more assertive.
"I was so close to desired level, and then I just completely underplayed that match".
"It would be really sad if I kept playing for years and my biggest goal was to get to the quarters of a Slam", she announced after her first-round victory.
This was not that day, although even at his absolute best he would have struggled to hold off Djokovic on this form.
Amid increasing noise between points and serves, which prompted frequent interventions from chair umpire Alison Hughes, the previously assured Djokovic - who missed the tournament past year due to an elbow injury - appeared agitated.
While Simona Halep of Romania retained her top spot on the list, Germany?s Angelique Kerber moved one spot up to acquire the third position. From there Djokovic comfortably served out the set. Little did anybody expect that in the next 16 years, across 64 Majors, not one or two but three players would stand shoulder to shoulder with the American great.
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Thereafter, there were two service holds and the set was poised at 3-2 and suddenly, Flushing Meadows saw a massive momentum shift.
On his own gruelling comeback from injury, Del Potro said: "I never gave up during my wrist problems".
Djokovic occasionally seemed annoyed by the support with the noise as British umpire Alison Hughes had to constantly plead with the crowd to remain quiet during points. He eventually succumbed to the mounting pressure in the third game as Djokovic looked to take over proceedings.
Djokovic will now set his sights on conquering a different summit by reclaiming his place atop the world tennis rankings for the first time since October 2016.
The end was near and when Djokovic put away a smash on a first match point, he fell onto the court on his back.
Serena Williams points the finger at umpire Carlos Ramos.
He broke Djokovic back with some brilliant movement on the court, leaving Djokovic stranded to take the third set back on serve.
Djokovic sprinted into a 3-1 lead in the third set before a battling Del Potro clung on, hitting back for 3-3.
Novak Djokovic and Juan Martin del Potro have begun their U.S. Open matchup between a pair of past champions.