The Argentine signed a long term contract with the club in May but has been linked with a move to Real Madrid, following Spanish media reports that current boss Julen Lopetegui could be sacked.
'The quality of the club, the players, the coaching staff and Pep (Guardiola) of course, make them a very hard opponent and it's a massive challenge for us to play against them.
"He did an incredible job at Espanyol and Southampton and especially here at Tottenham". "For me, he's one of the best managers and I admire him a lot".
The central midfielder was named as Tottenham's best first-year academy scholar by the Guardian this month, and is highly-regarded in north London.
"I like that, after what happened in Manchester at the arena, now it is a song for the people".
City and Liverpool have been talked about as the major threats to win the title this season, and the duo are two points clear at the top.
"When you play against the contenders it's nearly six points", added Guardiola.
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Guardiola started his senior managerial career with Barcelona and after winning everything with the Catalans, Pep Guardiola moved to Bayern Munich.
But Guardiola is keen to ensure the Premier League champions have no excuses and insisted the worn-down Wembley is not a concern.
"These are important. I don't know what's happened in the past but it's true that the strong teams are making a lot of points, they are not dropping points easily".
"That's why maybe the games against the contenders are becoming so important".
Pochettino's most recent encounters with Guardiola do not make for such good reading, with City running out 4-1 and 3-1 winners last season on their way to a dominant title triumph. And of course always when we arrive at like a final game, we always fail. The mentality is to win and to reach the last level.
"Except Anfield (away to Liverpool) and Man United at home, we won everything in the second season". When you win, he doesn't win.
"To play in Wembley, Milton Keynes - different circumstances, so we have to say "come on, if we are realistic, we need to celebrate the position we are in and receive praise for that" but it doesn't matter if we don't get praise". "Normally injuries happen when they are not 100 per cent focused".