Messi, who missed Barcelona's 5-1 thrashing of Real Madrid in last Sunday's El Clasico which led to the sacking of Julen Lopetegui, was reportedly set to be absent for three weeks.
The Catalans sit top of Group B after winning all three of their matches so far.
As the video shows, Messi has scored goals against AC Milan, Roma, Juventus but he has not scored against Inter Milan in three different occasions and given his injury and well-being, it is highly unlikely that Messi would make a fourth appearance against Inter and ultimately break the deadlock. We expect them to have a little more pressing and pressure high up the pitch.
According to the report: "If the game at Camp Noù served as a tension breaker of the fact that Icardi used to be a Barcelona player, tonight against Barcelona at the San Siro it must be Mauro Icardi's game".
Lionel Messi made the trip with Barcelona but is unlikely to play as he continues to recover from a fractured arm.
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Rayo Vallecano fans were in good mood during the last seven minutes of the game thinking their team would record an emphatic win over Barcelona.
The Argentinean wizard had not received the medical all-clear before travelling to Milan.
At the back, Sergi Roberto, Gerard Pique, Clement Langlet and Jordi Alba are all likely to start. Sergio Busquets and Ivan Rakitic are the other two players completing the midfield trio, with the experienced heads bringing a sense of calm in the middle of the park.
Luis Enrique is yet to pick him for Spain but it would be hard to justify ignoring the full-back again when the next squad is announced later this week.